mcr10 MTB000072

ncRNA Putative small regulatory RNA

This is an RNA, not a coding gene: it belongs to a separate track and carries none of the protein evidence layers.

Location

1283693–1283815 (+ strand), 123 nt, on H37Rv (NC_000962.3). Overlaps: Rv1157c. Upstream neighbour Rv1156 (800 bp). Downstream neighbour Rv1158c (364 bp).

Intra-MTBC variation

Coverage control

Variant density inside this RNA: 79.7 sites/100 bp, versus 58.0 in the flanking ±500 bp (GC 71.5 %). The flanks act as an internal witness: if variants are called normally around the RNA but none becomes widespread inside it, the constraint is real rather than a sequencing gap.

Verdict: n/a (a des variants communs)

Predicted secondary structure

60.2 % of bases are paired in the minimum-free-energy fold (74 paired, 49 unpaired). Folded in isolation; the in vivo structure may differ (partners, co-transcriptional folding).

Literature no publication

No mention of 'mcr10' anywhere in the TB literature corpus.

Read with care. Absence of literature does not imply absence of function; simply that no primary study addresses this locus under this name.

Sweep: tbmonitor TB corpus (~330k PubMed abstracts), single grouped UNION-ALL sweep of 2026-08-17 over the 72 ncRNA never previously searched; positive controls MTS2823 (6 papers), mcr11 (3), mcr7 (2) all returned their known hits, so a zero here is a measured absence and not a broken query.

Legacy record

mcr10, putative small regulatory RNA (See DiChiara et al., 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC Pasteur, 3'-end not mapped, ~118 nt band detected by Northern blot.

Sources

• Descriptive record (locus, name, product, comment, coordinates): Mycobrowser v5, stable RNAs (Kapopoulou et al. 2011, doi:10.1016/j.tube.2010.09.006).
• Intra-MTBC variation and coverage control: computed for this atlas over 145,209 genomes.
• Secondary structure: ViennaRNA 2.7.2, MFE fold.

← all RNAs