ncRv1617 MTB000137
ncRNA Putative small regulatory RNA
This is an RNA, not a coding gene: it belongs to a separate track and carries none of the protein evidence layers.
Location
1816131–1816235 (+ strand), 105 nt, on H37Rv
(NC_000962.3).
Overlaps: Rv1617.
Upstream neighbour Rv1616
(50 bp).
Downstream neighbour Rv1618
(1380 bp).
Intra-MTBC variation
| Genomes surveyed | 145,209 |
| Variable sites | 74 |
| Variants reaching 0.1 % of genomes | 0 |
| Carriers of the most widespread variant | 21 |
Coverage control
Variant density inside this RNA: 70.5 sites/100 bp, versus 69.3 in the flanking ±500 bp (GC 70.5 %). The flanks act as an internal witness: if variants are called normally around the RNA but none becomes widespread inside it, the constraint is real rather than a sequencing gap.
Verdict: COUVERTURE OK -> invariance biologique plausible
Read with care: constraint is not function. This RNA mutates like its surroundings, but no variant spreads through the population — which is evidence of selection acting on it, not evidence of what it does. Secondary-structure pairing was tested across the RNA set and did not explain this constraint.
Predicted secondary structure
68.6 % of bases are paired in the minimum-free-energy fold (72 paired, 33 unpaired). Folded in isolation; the in vivo structure may differ (partners, co-transcriptional folding).
Literature no publication
No mention of 'ncRv1617' anywhere in the TB literature corpus.
Read with care. Absence of literature does not imply absence of function; simply that no primary study addresses this locus under this name.
Sweep: tbmonitor TB corpus (~330k PubMed abstracts), single grouped UNION-ALL sweep of 2026-08-17 over the 72 ncRNA never previously searched; positive controls MTS2823 (6 papers), mcr11 (3), mcr7 (2) all returned their known hits, so a zero here is a measured absence and not a broken query.
Legacy record
Supported by sRNA-Seq in H37Rv (see DeJesus et al. 2017)
Sources
- Descriptive record (locus, name, product, comment, coordinates): Mycobrowser v5, stable RNAs (Kapopoulou et al. 2011, doi:10.1016/j.tube.2010.09.006).
- Intra-MTBC variation and coverage control: computed for this atlas over 145,209 genomes.
- Secondary structure: ViennaRNA 2.7.2, MFE fold.