C8 MTB000059
ncRNA Possible 4.5S RNA in signal recognition particle (small cytoplasmic RNA) (SC-RNA)
This is an RNA, not a coding gene: it belongs to a separate track and carries none of the protein evidence layers.
Location
4168154–4168281 (- strand), 128 nt, on H37Rv
(NC_000962.3).
Intergenic (no overlapping coding sequence).
Upstream neighbour Rv3722c
(26 bp).
Downstream neighbour Rv3723
(255 bp).
Intra-MTBC variation
| Genomes surveyed | 145,209 |
| Variable sites | 61 |
| Variants reaching 0.1 % of genomes | 1 |
| Carriers of the most widespread variant | 797 |
Coverage control
Variant density inside this RNA: 47.7 sites/100 bp, versus 56.3 in the flanking ±500 bp (GC 68.8 %). The flanks act as an internal witness: if variants are called normally around the RNA but none becomes widespread inside it, the constraint is real rather than a sequencing gap.
Verdict: n/a (a des variants communs)
Predicted secondary structure
60.9 % of bases are paired in the minimum-free-energy fold (78 paired, 50 unpaired). Folded in isolation; the in vivo structure may differ (partners, co-transcriptional folding).
Legacy record
C8, possible 4.5S RNA (See Arnvig and Young, 2009; DiChiara et al., 2010), part of signal recognition particle with protein Ffh. Alternate 3'-ends at positions 4168212 and 4168224.
Sources
- Descriptive record (locus, name, product, comment, coordinates): Mycobrowser v5, stable RNAs (Kapopoulou et al. 2011, doi:10.1016/j.tube.2010.09.006).
- Intra-MTBC variation and coverage control: computed for this atlas over 145,209 genomes.
- Secondary structure: ViennaRNA 2.7.2, MFE fold.