AS1726 MTB000055
ncRNA Putative small regulatory RNA
This is an RNA, not a coding gene: it belongs to a separate track and carries none of the protein evidence layers.
Location
1952291–1952503 (- strand), 213 nt, on H37Rv
(NC_000962.3).
Overlaps: Rv1726.
Upstream neighbour Rv1725c
(540 bp).
Downstream neighbour Rv1727
(767 bp).
Intra-MTBC variation
| Genomes surveyed | 145,209 |
| Variable sites | 142 |
| Variants reaching 0.1 % of genomes | 3 |
| Carriers of the most widespread variant | 1,684 |
Coverage control
Variant density inside this RNA: 66.7 sites/100 bp, versus 73.8 in the flanking ±500 bp (GC 66.7 %). The flanks act as an internal witness: if variants are called normally around the RNA but none becomes widespread inside it, the constraint is real rather than a sequencing gap.
Verdict: n/a (a des variants communs)
Predicted secondary structure
62.0 % of bases are paired in the minimum-free-energy fold (132 paired, 81 unpaired). Folded in isolation; the in vivo structure may differ (partners, co-transcriptional folding).
Literature cited
Quantified in a named diagnostic-biomarker sRNA panel (qRT-PCR on plasma or culture supernatant of TB patients); no functional characterisation of this sRNA specifically.
Read with care. Detected in a biomarker assay is not a demonstrated function — same distinction as an antigen status not being a molecular function (P16.16a, Rv2627c).
- Fu Y, Li W, Wu Z, Tao Y, Wang X, Wei J, Jiang P, Wu J, Zhang Z, Zhang W, Zhao J, Zhang F (2018) Detection of mycobacterial small RNA in the bacterial culture supernatant and plasma of patients with active tuberculosis. Biochemical and Biophysical Research Communications. doi:10.1016/j.bbrc.2018.04.165, PMID 29723507.
Sweep: tbmonitor TB corpus (~330k PubMed abstracts), single grouped UNION-ALL sweep of 2026-08-17 over the 72 ncRNA never previously searched; positive controls MTS2823 (6 papers), mcr11 (3), mcr7 (2) all returned their known hits, so a zero here is a measured absence and not a broken query.
Legacy record
AS1726, putative small regulatory RNA (See Arnvig and Young, 2009). Alternate 5'-ends at positions 1952400, 1952375, 1952367, and 1952351.
Sources
- Descriptive record (locus, name, product, comment, coordinates): Mycobrowser v5, stable RNAs (Kapopoulou et al. 2011, doi:10.1016/j.tube.2010.09.006).
- Intra-MTBC variation and coverage control: computed for this atlas over 145,209 genomes.
- Secondary structure: ViennaRNA 2.7.2, MFE fold.