mpr18 MTB000071
ncRNA Fragment of putative small regulatory RNA
This is an RNA, not a coding gene: it belongs to a separate track and carries none of the protein evidence layers.
Location
4093468–4093522 (+ strand), 55 nt, on H37Rv
(NC_000962.3).
Intergenic (no overlapping coding sequence).
Upstream neighbour Rv3651
(590 bp).
Downstream neighbour Rv3652
(110 bp).
Intra-MTBC variation
| Genomes surveyed | 145,209 |
| Variable sites | 49 |
| Variants reaching 0.1 % of genomes | 0 |
| Carriers of the most widespread variant | 61 |
Coverage control
Variant density inside this RNA: 89.1 sites/100 bp, versus 79.0 in the flanking ±500 bp (GC 69.1 %). The flanks act as an internal witness: if variants are called normally around the RNA but none becomes widespread inside it, the constraint is real rather than a sequencing gap.
Verdict: COUVERTURE OK -> invariance biologique plausible
Read with care: constraint is not function. This RNA mutates like its surroundings, but no variant spreads through the population — which is evidence of selection acting on it, not evidence of what it does. Secondary-structure pairing was tested across the RNA set and did not explain this constraint.
Predicted secondary structure
61.8 % of bases are paired in the minimum-free-energy fold (34 paired, 21 unpaired). Folded in isolation; the in vivo structure may differ (partners, co-transcriptional folding).
Legacy record
mpr18, fragment of putative small regulatory RNA (See DiChiara et al., 2010), ends not mapped, 82 and 100 nt bands detected by Northern blot in M. bovis BCG Pasteur.
Sources
- Descriptive record (locus, name, product, comment, coordinates): Mycobrowser v5, stable RNAs (Kapopoulou et al. 2011, doi:10.1016/j.tube.2010.09.006).
- Intra-MTBC variation and coverage control: computed for this atlas over 145,209 genomes.
- Secondary structure: ViennaRNA 2.7.2, MFE fold.