MTBC Gene Atlas

mcr7 MTB000067

ncRNA Putative small regulatory RNA

This is an RNA, not a coding gene: it belongs to a separate track and carries none of the protein evidence layers.

Location

2692172–2692521 (+ strand), 350 nt, on H37Rv (NC_000962.3). Overlaps: Rv2395A. Upstream neighbour Rv2395 (97 bp). Downstream neighbour Rv2395B (30 bp).

Intra-MTBC variation

Genomes surveyed145,209
Variable sites326
Variants reaching 0.1 % of genomes 6
Carriers of the most widespread variant300

Coverage control

Variant density inside this RNA: 93.1 sites/100 bp, versus 79.8 in the flanking ±500 bp (GC 69.7 %). The flanks act as an internal witness: if variants are called normally around the RNA but none becomes widespread inside it, the constraint is real rather than a sequencing gap.

Verdict: n/a (a des variants communs)

Predicted secondary structure

70.9 % of bases are paired in the minimum-free-energy fold (248 paired, 102 unpaired). Folded in isolation; the in vivo structure may differ (partners, co-transcriptional folding).

Literature characterised

PhoP-dependent ncRNA that modulates the ESX-1-associated Tat secretion system (Solans et al. 2014).

Sweep: tbmonitor TB corpus (~330k PubMed abstracts), single grouped UNION-ALL sweep of 2026-08-17 over the 72 ncRNA never previously searched; positive controls MTS2823 (6 papers), mcr11 (3), mcr7 (2) all returned their known hits, so a zero here is a measured absence and not a broken query.

Legacy record

mcr7, putative small regulatory RNA (See DiChiara et al., 2010). 5'-end mapped by 5'RLM-RACE in M. bovis BGC Pasteur, 3'-end not mapped.

Sources

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