MTBC Gene Atlas

Functional interaction network

STRING v12 network (guilt-by-association). Node colour = annotation verdict, dashed outline = still hypothetical; edge colour = evidence type, width ∝ score. Drag nodes to rearrange, hover to highlight neighbours, click a partner to re-centre, click the centre to open its gene page.

Centre Rv0136 · 46 genes shown · open gene page → · ← back to 1 hop

Evidence: Min score 0
cyp138 (requalified) — cytochrome P450 cyp138 pks13 (requalified) — polyketide synthase Pks13 pks13 Rv0135c (family_assigned) — helix-turn-helix domain-containing protein Rv0135c mbtE (requalified) — peptide synthetase mbtE Rv1937 (requalified) — FAD-binding oxidoreductase Rv1937 fdxB (requalified) — fatty acid desaturase fdxB kshB (family_assigned) — 3-ketosteroid-9-alpha-hydroxylase reductase subuni kshB Rv2776c (requalified) — oxidoreductase Rv2776c rplF (requalified) — 50S ribosomal protein L6 rplF polA (requalified) — DNA polymerase I polA pks1 (requalified) — polyketide synthase pks1 ppsB (requalified) — phthiocerol type I polyketide synthase PpsB ppsB pks2 (requalified) — phthioceranic/hydroxyphthioceranic acid synthase pks2 mbtH (requalified) — mycobactin NRPS accessory protein MbtH mbtH mbtB (requalified) — phenyloxazoline synthase MbtB mbtB fas (requalified) — fatty acid synthase fas nrp (requalified) — non-ribosomal peptide synthetase Nrp nrp fadD32 (requalified) — long-chain-fatty-acid--AMP ligase FadD32 fadD32 accD4 (family_assigned) — acyl-CoA carboxylase subunit beta accD4 Rv1645c (family_assigned) — oxygenase MpaB family protein Rv1645c pth (requalified) — aminoacyl-tRNA hydrolase pth Rv0275c (family_assigned) — transcriptional regulator Rv0275c Rv1353c (family_assigned) — TetR/AcrR family transcriptional regulator C-termi Rv1353c Rv3430c (requalified) — transposase Rv3430c mbtC (requalified) — polyketide synthetase MbtC mbtC mbtF (requalified) — peptide synthetase mbtF mbtG (requalified) — NADPH-dependent L-lysine N(6)-monooxygenase MbtG mbtG fadH (requalified) — NADPH-dependent 2%2C4-dienoyl-CoA reductase fadH fprB (requalified) — FAD-dependent oxidoreductase fprB fprA (requalified) — ferredoxin--NADP(+) reductase FprA fprA gltD (family_assigned) — glutamate synthase subunit beta gltD ephB (requalified) — epoxide hydrolase EphB ephB ribA1 (requalified) — riboflavin biosynthesis protein RibA ribA1 Rv1465 (family_assigned) — SUF system NifU family Fe-S cluster assembly prote Rv1465 iscS (family_assigned) — cysteine desulfurase family protein iscS mas (requalified) — mycocerosate synthase mas pks5 (requalified) — sulfolipid-1 biosynthesis phthioceranic/hydroxypht pks5 pks12 (requalified) — type I polyketide synthase pks12 kshA (family_assigned) — 3-ketosteroid-9-alpha-hydroxylase subunit KshA kshA kstD (requalified) — 3-oxosteroid 1-dehydrogenase kstD hsaC (requalified) — iron-dependent extradiol dioxygenase HsaC hsaC hsaA (family_assigned) — flavin-dependent monooxygenase oxygenase subunit H hsaA Rv3572 (family_assigned) — hypothetical protein Rv3572 cyp123 (requalified) — cytochrome P450 cyp123 cyp142 (requalified) — steroid C26-monooxygenase Cyp142 cyp142 Rv2777c (requalified) — metal-dependent hydrolase Rv2777c

edges: ▬ experimental/database (measured) · ▬ genomic-context · ▬ co-expression / other  |  nodes: ● resolved · ● family assigned · ● dark · dashed = hypothetical.